| Name | DABCYL-TNF-a-EDANS (-4 to +6) MS Grade peptide |
|---|---|
| Cat# | CPWHB102016 |
| Synonyms | Inquiry |
| Description | TACE FRET substrate I that is derived from the cleavage sequence of pro-TNFa recognized by the TNFa-cleaving enzyme (TACE). TNFa is presumably shed from cell membranes by TNFa-cleaving enzyme (TACE). Incubation of the TACE substrate with recombinant human TACE gives a specific cleavage to restore the quenched fluorescence. The substrate is widely used to screen inhibitors of TNF-convertase. |
| Chemical Formula | C70H104N22O18S1 |
| Molecular Weight | 1573.8 Da |
| Sequence | DABCYL-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-EDANS |
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