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DABCYL-TNF-a-EDANS (-4 to +6) MS Grade peptide


Product Description

NameDABCYL-TNF-a-EDANS (-4 to +6) MS Grade peptide
Molecular Weight1573.8 Da
Chemical FormulaC70H104N22O18S1
DescriptionTACE FRET substrate I that is derived from the cleavage sequence of pro-TNFa recognized by the TNFa-cleaving enzyme (TACE). TNFa is presumably shed from cell membranes by TNFa-cleaving enzyme (TACE). Incubation of the TACE substrate with recombinant human TACE gives a specific cleavage to restore the quenched fluorescence. The substrate is widely used to screen inhibitors of TNF-convertase.

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