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Colivelin, MS Grade Peptide


Product Description

NameColivelin, MS Grade Peptide
Molecular Weight2645.14
Chemical FormulaC119H206N32O35
DescriptionColivelin is a hybrid peptide which mediates neuroprotection against Alzheimer's disease (AD)-relevant insults. It is composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA(C8R)HNG17, a potent humanin derivative. Colivelin completely suppressed death induced by overexpressing familial AD-causative genes and amyloid b-protein (1-43) (H-1586) at a concentration of 100 fM. Intraperitoneally administered peptide suppressed memory impairment caused by the muscarinic acetylcholine receptor antagonist, 3-quinuclidinyl benzylate, indicating that a substantial portion of intraperitoneally administered colivelin passes through the blood brain barrier.

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