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H-Cys-Val-2-Nal-Met-OH, MS Grade Peptide


Product Description

NameH-Cys-Val-2-Nal-Met-OH, MS Grade Peptide
Molecular Weight548.73
Chemical FormulaC26H36N4O5S2
DescriptionDisruption of the function of the Ras oncogene represents a target in the search of anticancer agents. This peptidomimetic derivative is the most potent synthetic inhibitor of p21ras farnesyltransferase (Ftase). It inhibited rat brain Ras Ftase activity in a dosedependent manner with an IC50 value of 12 nM. Aromatic ring replacement by naphthylalanine maintained the intrinsic potency.

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